BYKdb: the Bacterial protein tYrosine Kinase database.

Fanny Jadeau (1) , Christophe Grangeasse (1) , Lei Shi (2) , Ivan Mijakovic (3) , Gilbert Deléage (4) , Christophe Combet (4)

1 IBCP - Institut de biologie et chimie des protéines [Lyon]
2 CGM - Centre de génétique moléculaire
3 Center for Microbial Biotechnology, BioCentrum,
4 BMSSI - Bases moléculaires et structurales des systèmes infectieux

Bacterial tyrosine-kinases share no resemblance with their eukaryotic counterparts and they have been unified in a new protein family named BY-kinases. These enzymes have been shown to control several biological functions in the bacterial cells. In recent years biochemical studies, sequence analyses and structure resolutions allowed the deciphering of a common signature. However, BY-kinase sequence annotations in primary databases remain incomplete. This prompted us to develop a specialized database of computer-annotated BY-kinase sequences: the Bacterial protein tyrosine-kinase database (BYKdb). BY-kinase sequences are first identified, thanks to a workflow developed in a previous work. A second workflow annotates the UniProtKB entries in order to provide the BYKdb entries. The database can be accessed through a web interface that allows static and dynamic queries and offers integrated sequence analysis tools. BYKdb can be found at http://bykdb.ibcp.fr.

Keywords: PHOSPHORYLATION

Domains: Life Sciences [q-bio]

Fanny Jadeau, Christophe Grangeasse, Lei Shi, Ivan Mijakovic, Gilbert Deléage, et al.. BYKdb: the Bacterial protein tYrosine Kinase database.. Nucleic Acids Research, 2012, 40 (Database issue), pp.D321-4. ⟨10.1093/nar/gkr915⟩. ⟨hal-00965572⟩